• Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study 

      Reiseter, Silje; Molberg, Øyvind; Gunnarsson, Ragnar; Lund, May Brit; Aaløkken, Trond Mogens; Aukrust, Pål; Ueland, Thor; Garen, Torhild; Brunborg, Cathrine; Michelsen, Annika; Abraityte, Aurelija; Hoffmann-Vold, Anna-Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-28)
      Introduction: Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage. The aim of this study was to examine the serum levels of the markers of neoangiogenesis: endostatin and vascular endothelial growth factor (VEGF), in our unselected cohorts of SSc and MCTD. Methods: Sera of SSc patients (N = 298) and MCTD ...
    • Lung CD4+ T cells in patients with lung fibrosis produce pro-fibrotic IL-13 together with IFNγ 

      Sikkeland, Liv Ingunn Bjoner; Qiao, Shuo Wang; Ueland, Thor; Myrdal, Ole Henrik; Wyrozemski, Lukasz Adam; Aukrust, Pål; Jahnsen, Frode Lars; Sjåheim, Tone Bjørg; Kongerud, Johny; Molberg, Øyvind; Lund, May Brit; Bækkevold, Espen Sønderaal (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
      Progressive fibrosing interstitial lung diseases (PF-ILD) have poor prognosis and survival, and their pathogenesis is not well understood[1]. Mechanistically, lung fibrosis is thought to result from distorted wound-healing following tissue insults and inflammation, leading to scar formation by excess deposition of extracellular matrix proteins and destruction of lung architecture[2]. The fibrotic ...